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Studies have shown that, in combined applications for disease treatment, this approach can reduce serum alanine aminotransferase and aspartate aminotransferase activities, improving liver function injury

B2R activation stimulated PRL secretion in males and inhibited PRL secretion in females, and stimulation of dopaminergic activity had an inhibitory effect on B2R gene expression in females but not in males

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The third group was based on the second one

The evidence regarding its impact on oxidative stress in migraine models remains limited, underscoring the need for careful consideration of dosages of topiramate and application conditions in the prophylactic treatment of migraines