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Riches et al., 2009)

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Intervention studies The findings of the six studies that report the outcome of interventions in autism focussed on normalising abnormalities in -glutamyl cycle or trans-sulphuration pathway metabolites [46, 48, 49, 54, 64] are presented in Table 11

Despite the myriad of ASMs available, 1/3 of the patients are considered drug-resistant or refractory (intractable epilepsy) (4, 5)

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