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Severe insulin resistance, particularly in patients with significant visceral adiposity or conditions like polycystic ovary syndrome, can attenuate tirzepatide's effectiveness

Fewer than 5% of patients experience persistent symptoms beyond 12 weeks of continuous therapy

Shipping delays, billing discrepancies, cancellation difficulties, and inconsistent customer service are recurring themes in customer reviews

The medication further slows gastric emptying, which could exacerbate pre-existing motility issues

You are unable to keep fluids down, or you are vomiting