To understand the dynamics of this interplay in T1DM, one must go back to the relation between portal insulin and GHR expression on hepatocytes, which was so cleverly addressed by Leung et al
However, significant risks and considerations must be weighed carefully: Gastrointestinal adverse effects : Both gastric sleeve and semaglutide delay gastric emptying and can cause nausea, vomiting, abdominal discomfort, and constipation
This approach is helpful for patients who are sensitive to medication changes, new to incretin-based therapies, or who have a history of significant GI-related side effects
Zepbound received FDA approval for weight management in 2023
Current GI symptoms : Mention any active gastrointestinal symptoms (nausea, vomiting, bloating) and whether you're in a dose-escalation phase, as these factors may influence perioperative planning
Waist circumference is a more informative marker of metabolic risk than body weight or BMI alone