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Cadenas, 1985
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Conclusions SIBO is a central gastrointestinal complication of SSc, arising from fibrosis, dysmotility, vascular injury, and immune dysregulation
It stimulates the pituitary gland to release growth hormone (GH), thereby regulating fat metabolism, promoting protein synthesis, and affecting bone and muscle growth
Mild, transient fluid retention/edema and joint or muscle pain, each reported more often on MK-677 than placebo in the same trial, linked to elevated GH and IGF-1
A faint headspace odor can be harmless, but a strong or persistent L-carnitine smell with visual changes is a red flag
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