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Given the lack of liver GLP-1R expression (136), the potential mechanism of actions of GLP-1R agonists in NASH may be related to the indirect beneficial effects on body weight, IR and reduction in metabolic dysfunction, lipotoxic effects and inflammation (137)

Support for B-vitamin deficiency-related neuropathies: may be considered in cases of peripheral neuritis, numbness, paresthesia, or neuropathic pain where B-vitamin deficiency is suspected or confirmed

All data and observations associated with this compound are strictly limited to laboratory-based scientific investigation

doi: 10.1038/nrm.2016.25 15 AebersoldRMannM