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doi: 10.1038/s41590-020-0751-0 206 KlarquistJHenniesCMLehnMARebouletRAFeauSJanssenEM

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Because MOTS-c enhances insulin-independent glucose uptake, patients with type 1 diabetes or those using exogenous insulin should be monitored carefully to prevent hypoglycemia, though this theoretical risk has not materialized in clinical reports to date

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Mice have different metabolic rates, body composition, and adipose tissue biology than humans

In cell culture studies, an anthocyanin-rich blueberry extract exhibited insulin-sensitizing properties, conferred protection against glucose and fatty acid toxicity, and enhanced proliferation of insulin-producing pancreatic beta cells (Martineau 2006