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A suitable controlled-release auris-acceptable microsphere example for use with the auris-acceptable therapeutic agents disclosed herein includes CHRONIJECT, a PLGA-based controlled release injectable drug delivery system

doi: 10.1016/j.jhep.2015.02.008 55 Koca-CaliskanU.YilmazI.TaslidereA.YalcinF

DSIP in normal physiological concentrations exhibits a marked diurnal variation and correlates with the circadian rhythm