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World J Microbiol Biotechnol 33

Disabling CBP/p300-binding to NRF2 broadly attenuated NRF2 transcriptional activity resulting in an altered metabolic (depletion of glutathione) and lipidomic (specific depletion of triglycerides) cellular landscape

Structurally, GRXs are very similar to thioredoxins, retaining the same fold and active sites

In our experimental setup, this A-anticalin solution was directly applied in vivo to the exposed hippocampal CA1 region 10,18 of 23-month-old APP23xPS45 mice, at a stage preceding the formation of A plaques 14

Cytokinetic analysis of tumor growth

For the in vivo detection of GSH and GSSG, techniques such as proton magnetic resonance spectroscopy, mass spectroscopy, electron paramagnetic resonance imaging, fluorescence imaging, and implanted biosensors have been explored [15]