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The LEADER trial with liraglutide and the REWIND trial with dulaglutide did not show significant increases in retinopathy complications, though differences in trial design, patient populations, baseline retinopathy prevalence, and rates of glycemic improvement may explain these discrepant findings

But few randomized clinical trials have been conducted of GLP-1s for treatment of AUD

Weight regain after liraglutide, semaglutide or tirzepatide interruption: a narrative review of randomized studies

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But how sustainable are such offerings

The drug has a long half-life, which means it can be administered monthly or less frequently, giving the drug the potential to improve adherence and long-term weight control, according to Jay Bradner, executive vice president of research and development at Amgen