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The intake of leucine or leucine-enriched protein, particularly when strategically aligned with resistance training, markedly augments MPS and functional strength in comparison to exercise in isolation (80)

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In REDEFINE 1, adverse events were mainly gastrointestinal (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)

Increasing again during that window can make an otherwise workable dose intolerable