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Since cancer is a chronic disease, T-cells within the lymph nodes are continuously exposed to cancer antigens resulting in the upregulation of CTLA-4 on their cell surface and inhibition of proper T-cell activation, disrupting anti-tumor cytotoxic T-cell functions that results in T-cell anergy (162164)

Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic lower extremity ulceration: Results of the HGF-0205 trial

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