These extremely rare side effects include: Reactive thrombocytosis during the first week of use in megaloblastic anaemia Hypersensitivity reactions including: rash, itching, exanthema, antibodies to HYDR0XOCOBALAMIN-transcobalamin II Anaphylaxis Hypokalaemia Headache, paraesthesia, tremor Irregular heartbeat (arrhythmias secondary to hypokalaemia) Nausea Vomiting Diarrhoea Fever, chills, hot flushes, dizziness, malaise, pain and / or swelling at the injection site Acne Abnormal colouration of the urine (chromaturia) What should you not do after a B12 shot
It is also dependent on the number of areas you want to be treated
Vitamin C in extremely high doses (more than 1000 mg taken with a b12 supplement) may reduce b12 absorption when taken together
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Polycythemia vera Because B12 stimulates red blood cell production, injections could worsen this blood disorder