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Developed in the 2000s and early 2010s at Washington State University as a candidate treatment for Alzheimer's disease and other neurodegenerative conditions

Rapamycin can reverse COX7A1-mediated autophagy blockade, synergistically enhancing ferroptosis under cysteine deprivation (57)

Front Immunol 4:230 Elder MJ, Webster SJ, Chee R, Williams DL, Hill Gaston JS, Goodall JC (2017) beta-Glucan size controls Dectin-1-Mediated immune responses in human dendritic cells by regulating IL-1beta production

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Wang X, Fang G, Yang J, Li Y (2017b) A thioredoxin-dependent glutathione peroxidase (OsGPX5) is required for rice normal development and salt stress tolerance