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Any differences relate to individual caffeine sensitivity, which depends on personal tolerance rather than gender

In particular, the choroid plexus epithelium acts as a key site of reduced glutathione (GSH)-dependent detoxification for the developing brain, at a period when neither the liver nor the astrocytic network are mature enough to fulfill this function [11, 13]

The findings should be interpreted with caution as there were some methodological flaws, as a number of studies were judged to be either at high or unclear risk of bias for many domains, the review states

diffusum have poor solubility, and the solvents have potential toxicity

2019 Mar 1;102(2):395-411

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