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A systematic review in 2014 of randomized and non-randomized trials by Ling Li et al

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As alluded to above, the rationale for combining GLP-1R agonism with either GIPR agonism or antagonism is, however, still debated, and how the GIPR agonistic properties of tirzepatide contribute to body-weight loss remains unclear [19]

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Here is what researchers most often study, all in animal or cell models: Cytoprotection: Much of the early work looked at how the peptide affects the stomach and gut lining in rodents