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In contrast, the changes in the right arm, right leg, left leg, android, and gynoid regions did not differ significantly from each other

Following administration of a combined oral contraceptive (0.035 mg ethinyl estradiol and 0.25 mg norgestimate) in the presence of a single dose of tirzepatide 5 mg, mean Cmax of ethinyl estradiol, norgestimate, and norelgestromin was reduced by 59%,66%, and 55%, while mean AUC was reduced by 20%, 21%, and 23%, respectively

Furthermore, the US FDA approval signifies a medications benefits overshadow its known and potential risks for the intended population and indications

doi: 10.1007/s43032-019-00118-0

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