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We proposed ASM as a mandatory model because allowing voluntary participation would likely result in only high performers joining the model, rather than incentivizing all clinicians to improve care

In clinical trials, once-weekly semaglutide at diabetes doses (0.51 mg) produces mean weight loss of 46 kg (913 lbs), while the 2.4 mg dose (Wegovy) achieves average weight reductions of 1215% of body weight

A single dose might transiently affect anxiety circuits

This sequence of biochemical events ultimately leads to the degeneration of cholinergic neurons and the subsequent emergence of cognitive deficits

Wegovy (semaglutide) [prescribing information]

10.1038/nm.4345 126 WuL.ZhouB.Oshiro-RapleyN.LiM.PauloJ