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Outright contraindications listed include a personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2, pregnancy, and severe renal or hepatic impairment

Patients receiving escitalopram should be monitored for the development of serotonin syndrome or NMS-like signs and symptoms

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The crystal structures of inhibitor-complexed forms also indicate that Gly-473 to Thr-475 forms an oxyanion hole, which interacts with the oxyanion of the tetrahedral intermediate in the transition state