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Simeon 2000 Life Sci simultaneously documented the stimulation of matrix repair and the suppression of degradation by MMP-2 and MMP-9 (matrix metalloproteases), a unique profile of constructive rather than destructive remodelling

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The prolyl hydroxylases that hydroxylate HIF -subunits (HIF1 and HIF2) are all 2-oxoglutarate (-ketoglutarate) and Fe 2+ -dependent enzymes (2OG-oxygenases)

Most available information comes from clinical trial protocols that don't translate easily to real-world use