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This can help with overstimulating your GI tract with large portions

Many patients experience gradual and sustainable weight reduction, with some studies showing an average loss of 5-15% of body weight over several months

And Saxenda really helped there

Other pharmacological options include different weight management medications such as phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), and orlistat (Xenical, Alli)

5,17 Metformin being a hydrophilic molecule has also been observed to have metal-binding properties, principally with copper