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doi:10.1056/NEJMoa2307563 Jastreboff AM, Kaplan LM, Frias JP, et al

Additionally, ketamine activates the NLRP3 inflammasome, inducing caspase-1 activation and neuronal pyroptosis, further contributing to neuroinflammation in regions, such as the hippocampus and prefrontal cortex (Zhang et al., 2021)