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doi: 10.1001/archneur.1981.00510010045007 17 JangHBoltzDSturm-RamirezKShepherdKRJiaoYWebsterRet al

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The Hayflick limit and why telomere length matters In 1961, Leonard Hayflick demonstrated that normal human cells have a finite replication capacity of approximately 50 to 70 divisions, after which they enter senescence or apoptosis

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As microarray analysis indicated upregulation of inflammatory genes shortly after injection of 6-OHDA [237], it may be possible that BBB leakage is first triggered by neuroinflammation and then driven by dopaminergic cell loss [236]