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Hepatic FGF21 and adiponectin are required to fully achieve BAT activation by G49 To gain more insights into FGF21 as a mediator of G49 actions in BAT activation, a cohort of hepatocyte-specific FGF21-deficient (FGF21 Alb-KO ) mice and their controls (Alb Cre ) fed a HFD were treated with G49 for 1 week

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