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PCOS Women with polycystic ovary syndrome represent one of the populations that may benefit most from retatrutide

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The GLP-1 weight loss approach is not limited to a hormonal mechanism but is part of a broader strategy that integrates diet, physical activity, and lifestyle habits

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The study cannot explain why lean body mass loss was greater with tirzepatide, which mimics the hormones GLP-1 and GIP, compared with semaglutide, which only mimics GLP-1

doi:10.1038/s41467-025-66522-0 Thompson PD, et al