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Humoral immunity involves autoreactive B cells and plasma cells that produce high-affinity antibodies against Tg and TPO, furthering tissue injury through complement activation and antibody-dependent cell-mediated cytotoxicity (ADCC)

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Yes, when administered by trained professionals

These findings support the potential therapeutic applications of TB-500 in musculoskeletal medicine

When paired with IL-17A, it offers a more complete view of pathway activation and disease mechanisms