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[1] [2] The decision to stop tirzepatide may arise from various circumstances: achievement of treatment goals, intolerable side effects, insurance coverage changes, cost considerations, pregnancy, or medical contraindications (including medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or serious hypersensitivity reactions, as noted in the boxed warning)

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Approaches such as intrathecal, intracerebroventricular, and intraparenchymal injections, as well as transient BBB disruption, have been employed to deliver drugs with limited CNS bioavailability (Ganger and Schindowski, 2018

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