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The study has several important caveats

Key DIO mouse-model findings: nimacimab added to tirzepatide produced 39% and 46% weight loss, effects were durable after discontinuation, rebound was blunted by ~ 80% , and weight loss was not driven primarily by caloric restriction

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Scientific American described retatrutide as part of a new class of GLP-1-related drugs that aims at three hormone receptors rather than one