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The recommended approach is to discontinue semaglutide, allow a washout period of at least 2-3 weeks (given semaglutide approximately one-week half-life), and then begin retatrutide titration from the standard 1 mg starting dose

Finally, and as a consequence of the above, DPP-4 inhibitors can exert their clinical effects even in advanced stages of type 2 diabetes

2025 Jan 8;17(1):14

& Schneider, F