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doi: 10.1021/acs.jafc.1c07805

(3) Hemodynamic Effects: Combined and effects result in a marked increase in cardiac output, decreased diastolic blood pressure, and reduced peripheral resistance, including vasodilation in skeletal muscle

Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D, and Loscalzo J (1993)

doi:10.1164/rccm.200909-1423OC

Metformin induces weight loss associated with gut microbiota alteration in non-diabetic obese women: a randomized double-blind clinical trial

Each study was classified as having low risk of bias (green), some concerns (yellow), or high risk of bias (red) (Figure 2)