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Combined with the structural changes to the Purkinje cells [179, 180], possible Purkinje cell loss [181], Purkinje cell axonal alterations, and/or abnormal Purkinje cell synaptic organization [182, 183] reported in postmortem human ET tissue, the VIM neurons are likely entrained by abnormal cerebellar activity

255 Whats more important, melanoma cells harboring BRAF mutation and hyper-activation of the MAPK pathway are highly dependent on leucine for survival

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[DOI] [PMC free article] [PubMed] [Google Scholar] Du X, Matsumura T, Edelstein D, Rossetti L, Zsengellr Z, Szab C, Brownlee M