Ferroptosis is characterised by increased levels of Fe2+ within cells, oxidative stress of polyunsaturated fatty acid phospholipids, and the accumulation of lipid peroxides [13, 14]
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Tammela, J., Geisler, J., Eskew, P
These results indicate that patient NPs rely on upregulated glycolysis to meet energy demands due to limited pyruvate oxidation, while retaining OXPHOS capacity when provided with anaplerotic substrates such as glutamine
Another possibility is the presence of a yet unidentified redox factor in the periplasm that can catalyze oxidative protein folding in the absence of DsbA