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(2) Clinical design deficiencies: most human trials utilize berberine chloride formulations not optimized for obesity-specific indications, coupled with inadequate endpoint selection targeting adiposity pathophysiology

Even though the doses are small, patients maintain regular communication with their care team to discuss symptom improvement and progress

[52] gave diet-induced obesity (DIO) mice daily GLP-1R/Gcg receptor (GcgR) double agonist (cotadutide), Lira, Gcg agonist (g1437), and Lira+g1437 respectively

While GLP-1s are effective for weight loss, they are not clinically appropriate for everyone

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Cytoprotection: organoprotection by somatostatin