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This receptor modulation triggers a cascade of intracellular signaling events that ultimately result in the activation of hormone-sensitive lipase, the enzyme responsible for breaking down stored triglycerides into free fatty acids and glycerol

Most neuropeptides are chains of amino acids that are broken down by digestive enzymes (pepsin, trypsin) in the stomach and small intestine

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Hydrolysis: HSL hydrolyzes triglycerides into free fatty acids (FFAs) and glycerol, which are then exported from the cell into the bloodstream to be used as fuel