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APAP adducts on mitochondrial proteins such as glycine amidinotransferase, Parkinson disease protein 7 (PARK7), peroxiredoxin 6 and voltage-dependent anion-selective channel protein 2 (VDAC2) have also been detected in cultures of human hepatocytes [34], indicating that adduct formation is not a global phenomenon affecting all mitochondrial proteins, but rather selective with specific targets
However, efficient and targeted intra-articular gene delivery remains a considerable technical challenge, primarily due to the dense extracellular matrix (ECM) of cartilage, rapid clearance of joint fluid, and limited cellular uptake
Books (edited and written) Walker AR, et al
Kassis ES, Vaporciyan AA, Swisher SG , Correa AM, Bekele N, Erasmus JJ, Hofstetter WL, Komaki R, Mehran RJ, Moran CA, Pisters KM, Rice DC, Walsh GL, Roth JA
These pathways contribute to systemic toxicity, increasing the risk of malignancies, cardiovascular diseases, and kidney dysfunction [31]
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