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Week 8-10 (Post-protocol): Retest everything you ran at baseline

Glutathione plays a crucial role in protecting cells from oxidative stress and supporting overall health

Among the genes downregulated in response to GSTO1 siRNA, coagulation factor III ( F3 ), thrombospondin 1 ( THBS1 ), cysteine-rich angiogenic inducer ( CYR61 ) and bone morphogenetic protein 4 ( BMP4 ), related to blood coagulation and blood vessel morphogenesis, were markedly decreased (Supplementary Table 11)

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Among these, DCA has been demonstrated to damage endothelial tight junctions, leading to increased BBB permeability (82)