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In the SURMOUNT-1 trial, participants on the highest dose (15 mg) of tirzepatide lost an average of 20.9% of their body weight over 72 weeks

[Article] [PubMed]115

For most people, diarrhea associated with semaglutide is mild and temporary

For MOTS-c, research protocols discussed in investigational contexts vary widely, but often involve subcutaneous administration of 5-15 mg, 2-3 times weekly

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Dosing & Reconstitution Guide Educational guide for reconstitution and weekly dosing Standard / Gradual Titration (3 mL = ~3.33 mg/mL total) Route: Subcutaneous injection