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VGCCs act as the primary electromagnetic effector, directly converting field-induced membrane depolarization into shifts in the extracellular Ca 2+ gradient that initiate intracellular signaling cascades, such as calcium-induced calcium release (CICR) [34] [Figure 1]

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A 38.8% Objective Response Rate (ORR) was achieved with ipilimumab and T-VEC when used in combination

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