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Although the genetic basis of many of the dystrophies has been known for over a decade and new disease genes continue to be discovered, the pathogenetic mechanisms leading to muscle cell death in the dystrophies remain a mystery
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RSC Med Chem 15:21652178
8 Future directions Conventional antioxidants face limitations in efficacy and specificity, but emerging strategiesincluding mitochondria-targeted compounds and Nrf2 activatorsaddress these challenges through three transformative mechanisms: Precision targeting Unlike broad-acting scavengers, these agents accumulate within mitochondria, the primary source of ROS
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