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Additionally, the release of inflammatory chemicals increases the severity and persistence of pain

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Five of the alternative mRNAs encode preproproteins that are processed into both the ghrelin-28 and obestatin proteins, while two of the mRNAs encode preproproteins that are processed into the ghrelin-27 and obestatin proteins, and the remaining three mRNAs encode preproproteins that lack the signal peptide and the ghrelin-28 sequences