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Tahata et al., 2018

When defects occur during DNA replication or chromosomal segregation and in case of DNA damage, the cell cycle can be transiently arrested at check points to allow for repair

Arterial stiffness, atherosclerosis and cardiovascular risk: pathophysiologic mechanisms and emerging clinical indications

De Araugo SC, Varney JE, McGuinness AJ, Naude C, Evans S, Mikocka-Walus A, et al

It has undergone a lot of clinical testing (the STEP trial program included more than 4,500 people) that shows it works and is safe, which supports regulatory submissions in big countries

This clinical oversight maintains safety while maximizing access for eligible candidates