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Decreased Excretion Acute or chronic kidney failure Hypoaldosteronism Adrenal insufficiency (Addisons disease) Potassium-sparing diuretics (e.g., spironolactone) 2

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Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen

Each one carries a boxed warning and safety precautions that a doctor will assess carefully

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