For instance, iron overload can enhance chondrocyte catabolism through overactivated NLRP3 inflammasomes, promoting MMP expression and exacerbating cartilage degeneration (Li S et al., 2023)
2025 set the tone with high-profile battles like the Metsera bidding war between Pfizer and Novo Nordisk which finally closed, with Pfizer winning, for $10bn [17] , underscoring the strategic value of next-generation assets such as Metseras long-acting injectable asset, MET-097i
Rather than individual concentrations, the proportion of N-3 to N-6 PUFAs is key for the effects on health, where a lower concentration of N-6 PUFAs and a higher concentration of N-3 PUFAs is considered healthy [34]
Cao C, et, al
Merkel cell carcinoma a firm, shiny, painless lump a round, raised lesion a fast-growing bump Although melanoma skin cancers are less common than non-melanoma ones, they are more dangerous
10.1016/j.jaci.2003.10.050 [DOI] [PubMed] [Google Scholar] 11.Yousefi S, Simon D, Simon H-U