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10.1038/nrendo.2016.153 25 NomiyamaT.KawanamiT.IrieS.HamaguchiY.TerawakiY.MuraseK.et al (2014)

Lastwika KJ, Wilson W 3rd, Li QK, Norris J, Xu H, Ghazarian SR, Kitagawa H, Kawabata S, Taube JM, Yao S, et al

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Studies were identified through search of trial registries and databases (Medline, Embase, PsycINFO, CINAHL, Cochrane, Web of Science) from inception through February 2025 for randomized controlled trials, nonrandomized comparative trials, and observational studies

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PT-141 effects are typically felt within 2-4 hours of administration, while Gonadorelin may take several weeks to months to show full benefits as it works to restore natural hormone production