Glutathione (L--glutamyl-L-cysteinyl-glycine) is the most abundant non-protein thiol in mammalian cells, present in millimolar concentrations throughout the body with particularly high concentrations in the liver, kidneys, and immune tissues
therefore, a GST 4QN tag could improve the reproducibility and reliability of GST pulldown experiments
Additionally, in SLE patients T cells, SIRT2 promotes Th17 cell differentiation and inhibits CD4 + T cell production of IL-2, correcting abnormal expression of IL-17A and IL-2, and benefiting CD4 + T cells in lupus prone mice and SLE patients (101)
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