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PMID: 167 MiyakeTAbeMTokumotoYHirookaMFurukawaSKumagiTet al

For selected patients, obesity treatment may involve more than one tool rather than a choice of medication or procedure alone

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While Nrf2 and JAK2/STAT3 have protective roles, severe oxidative stress can also lead to their dysregulation or interaction with other pathways in ways that contribute to later-stage remodeling or inflammation (Mahdiani et al., 2022

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They fail others entirely