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Oral GLP-1 may feel more approachable at the outset, but for many patients, injections become the easier long-term habit

The bioavailability difference is dramatic, which is why people feel and see the IV version so much more

The primary hypothesized mechanisms involve the alteration of neuronal resting membrane potentials, modulation of synaptic function, and activation of functional brain network connectivity

doi: 10.1007/s10265-015-0757-0 84 ZhengY.LuoL.WeiJ.ChenQ.YangY.HuX.et al

Third, medication exposure was based on prescription fills, not direct consumption, which may overestimate the exposure to GLP-1RA and bias estimates, though this is a well-established pharmacoepidemiologic method

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