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PubMed, Esposito, Gianluca, et al
clinical development was subsequently discontinued by Metabolic Pharmaceuticals
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The same finding has not yet been confirmed in clinical trials, although there is evidence of striatal vascular formation within cerebral capillaries during the progression of PD (Yang et al
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The Maastricht VI/Florence Consensus Report (2021) does not recommend routine probiotic supplementation due to inconsistent clinical evidence regarding efficacy ( Probiotic treatment may also lead to adverse effects, such as exacerbated constipation and bloating, and its safety profile requires further investigation
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