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With neurological involvement: 1 mg intramuscularly daily on alternate days until no further improvement, then 1 mg every 2 months

Avoid unsupported claims about their efficacy

It remains useful for estimating near-term probability, particularly in older adults where the short-term horizon and absolute risk align more closely

If you miss a dose, most protocols suggest taking it as soon as you remember, provided the next scheduled dose is at least 3 days (72 hours) away

Casarini L, Crpieux P, Reiter E, et al

Patients should disclose all current medications, including prescription drugs, over-the-counter medicines, herbal products, vitamins, and nutritional supplements