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117 SIRT1 also activates FOXO3a, which upregulates autophagy-related genes such as Atg5 and Atg7 , promoting autophagosome formation and reducing ROS levels, thereby attenuating inflammation
Author contributions WQ designed the research and analyzed the data and wrote the manuscript
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Dora Matis - April 13, 2026 GLP-1 receptor agonists such as semaglutide-based medications support blood sugar control, weight loss, and cardiovascular health through effects on insulin, appetite, and gastric emptying
Evidence suggests that GLP-1 pathways influence the central nervous system via multiple routes: some agents and/or their downstream effects reach or affect the brain and bloodbrain barrier , altering glucose transport, microglial activation, and synaptic function in preclinical and early human studies
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